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Author: Suzuki, H.; Komiya, A.; Aida, S.; Akimoto, S.; Shiraishi, T.;
Yatani, R.; Igarashi, T.; Shimazaki, J.
Year: 1995
Title: Microsatellite instability and other molecular abnormalities
in human prostate cancer
Journal: Jpn J Cancer Res
Volume: 86
Issue: 10
Pages: 956-61
Label: 96096811
Keywords: Adenocarcinoma/*genetics
DNA, Neoplasm/*genetics
Genes, p53
Genetic Markers
Human
Japan
Male
*Microsatellite Repeats
Mutation
Polymorphism, Single-Stranded Conformational
Prostatic Neoplasms/*genetics
Receptors, Androgen/genetics
Support, Non-U.S. Gov't
Abstract: Microsatellites are highly polymorphic, short-tandem repeat
sequences dispersed throughout the genome. Instability of these
repeat sequences at multiple genetic loci may result from mismatch
repair errors, and occurs in hereditary nonpolyposis colorectal
carcinoma and certain sporadic cancers. To examine microsatellite
instability during the pathogenesis of human prostate cancer,
we screened 48 prostate cancer cases (20 stage B, 10 stage C and
18 endocrine therapy-resistant cancer- death cases) for replication
error at 17 microsatellite marker loci on 9 chromosomes. Microsatellite
instabilities were found in 7 of 48 cases (14.6%), and all 7 cases
showing the instability were poorly differentiated adenocarcinomas.
Moreover, microsatellite instabilities were more frequently observed
in cancer-death cases (6/18, 33%) than in stage B + C cases (1/30,
3.3%). These data suggest that microsatellite instability is an
important genetic change related to the progression of a subset
of human prostate cancer cases. It is suggested to be associated
with extensive, concurrent molecular changes including androgen
receptor gene mutations, as well as frequent loss of heterozygosity
at chromosomal regions 8p, 10q, and 16q.